Allele iPSCs Advancing Research 5/19/2014


Allele iPSCs Advancing Research

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Barth syndrome is an X linked genetic disorder affecting multiple body systems, most commonly causing cardiomyopathy, neutropenia and skeletal muscle underdevelopment. We are proud to report that a recent publication from the Pu lab at the Boston Children's Hospital used Allele Biotech's iPSCs to help model and study Barth syndrome. Published in the Journal Nature Medicine, "Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies" features a a number of authors who are well renowned in their fields of study, including George Church PhD, Richard Kelley PhD, and Kenneth Chien PhD. The research carried out for this publication has led to a greater understanding of Barth Syndrome which could lead to new treatment strategies.

In the publication described above researchers used 2.5x Nucleotide Mix with Cap Analog to generate modified mRNA for iPSC reprogramming. This convenient mix is ready for direct use in in vitro transcription reactions. We want you to try this reagent out today, so for a limited time get 10% off your order of 2.5x Nucleotide Mix with Cap Analog when you use the code MIX10. For more details visit our promotions page.