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mRNA can mediate rapid and transient expression of temporally critical genes or reporters that need strong signals, as it only needs to cross the cell membrane, unlike DNA or most viral vectors, to be transcribed then translated.

Commonly used reporters like fluorescent proteins and luciferase can be efficiently expressed as mRNA, especially using Allele Reagent’s palette of the brightest fluorescent proteins in their spectral group*.

Allele’s custom mRNA service team can integrate these reporters into subcellular localization-specific markers, of which membrane-bound mNeonGreen mRNA and nuclear mScarlet3 are outstanding examples.

Similarly, these reporters can be integrated into various sensors, such as:

Group Ions: Ca²⁺, voltage, Cl⁻, SO₄²⁻, K⁺

Group Signals: auxin, diacylglycerol (DAG), cAMP, Notch signaling

Even when encoding the same gene, the chemical structures of mRNA—such as the type of cap or modified bases—and physical properties can lead to species-specific differences in expression and function.

*mNeonGreen, mWasabi, mMaple (photoconvertible), mTFP1, mTurquoise, mScarlet, and mScarlet3