TALEN Technology and Genome Editing - 6/27/2013



Allele Biotech is proud to announce our new line of FastTale Talen assembly kits. TALEN (Transcription Activator-Like Effector Nucleases) mediated gene targeting is a newly developed technology used for genetic targeting and editing. Compared to other genome engineering tools, such as zinc-finger nuclease (ZFN) and meganuclease, TALEN offers more versatility and flexibility in targeting specific DNA sequences, at any location, in any gene, and within any genome. The discovery of TALEN has evoked a series of applications and publications, and has been one of the most effective genome engineering tools available now. TALEN was elected as ‘Method of the Year 2011’ by Nature Methods.

Genome editing is a method using engineered nucleases, to splice and generate precise double-stranded breaks (DSB) at intended locations in the genome, using the cell’s endogenous mechanisms to repair the induced break by natural processes of homologous recombination and nonhomologous end-joining. This type of genetic engineering is particularly useful for a multitude of applications such as: targeted gene mutation, creating transgenic animals, and chromosome rearrangement. We believe our FastTale kits are an excellent option for anyone who in interested in genome editing and would like an accessible easy to use format.

If you have any questions about our TALEN kits or technology please email us at info@allelebiotech.com or call us at 800-991-7624.

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