SOX2 mRNA

Sox2 encodes a transcription factor belonging to the SOX (SRY-box) family, characterized by a high-mobility group (HMG) DNA-binding domain. It plays a key role in early embryonic patterning and cell-fate specification. Sox2 activity is essential for sustaining neural stem and progenitor populations within the central nervous system and also contributes to transcriptional regulation in gastric tissues. When ectopically introduced together with select partner factors, Sox2 can facilitate the reprogramming of somatic cells into induced pluripotent stem cells.